Bioactive Small Molecules
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Filtered Search Results
Apexbio Technology LLC Ro3280, 50mg. Cas: 1062243-51-9 MFCD: MFCD22665717. PLK1 inhibitor,potent and highly selective
Ro3280 is a selective inhibitor of PLK1 with IC50 value of 3 nM [1]. Polo-like kinase 1 (PLK1) is an enzyme and plays an important role in regulating cell cycles as an early trigger for G2/M phase transition. Other sizes are available. Please inqury us for quote.
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Apexbio Technology LLC Cy7 carboxylic acid (non-sulfonated), 25mg
Cy7 carboxylic acid is a near-infrared fluorescent dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. Other sizes are available. Please inqury us for quote.
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Apexbio Technology LLC HC-030031, 50mg. Cas: 349085-38-7 MFCD: MFCD02007349. TRPA1 channel blocker,potent and selective
HC-030031 is a selective antagonist of transient receptor potential ankyrin subfamily, member 1(TRPA1) with IC50 value of 4.9M [1].TRP channels are found to take participate in the response of chemical stimuli and in mechanoreception. Other sizes are available. Please inqury us for quote.
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Apexbio Technology LLC LY2603618, 10mM (in 1mL DMSO) CAS# 911222-45-2
LY2603618 is a novel small molecular checkpoint kinase 1 (Chk1) inhibitor that has direct anti-tumour effect [1], as well as desensitizing tumour cell against DNA-damaging chemotherapy treatment [2].Checkpoint kinase 1 (Chk1) is a type of kinase that coordinates damaged-DNA repair [1]. Some tumour cells have been found to possess over-regulated populations of Chk1 that desensitize the cell from DNA-targeting chemotherapy, promoting tumour proliferation [3].LY2603618 inhibits Chk1 by competing with ATP molecules [2]. In A549 and H1299 non-small cancer cell lines, lethal concentration of LY2603618 (10 M) not only resulted in cell proliferation arrest (increase population of cell at G2/M phase from 13% to 38%) but also directly DNA damage, the latter of which was indicated by the increasing occurrence of H2AX phosphorylation[1]. Other sizes are also available. Please inqury us for quote.
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Medchemexpress LLC HY-N6882 1mg Medchemexpress, Genistein 8-c-glucoside CAS:66026-80-0 Purity:>98%
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Medchemexpress, HY-N6882 1mg Genistein 8-c-glucoside CAS:66026-80-0 Genistein 8-c-glucoside (G8CG) is a natural glucoside isolated from flowers of Lupinus luteus L. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces apoptosis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC ErSO-DFP | 2768139-76-8 | 99.6% | C20H17F5N2O2 | 50 MG
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ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. It demonstrates enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells, offering a wider selectivity window. This compound exhibits antitumor activity against MCF-7 in mice and can effectively cross the blood-brain barrier.
- Anticipatory unfolded protein response (a-UPR) activator
- Enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells
- Wider selectivity window
- Displays antitumor activity against MCF-7 in mice
- Can cross the blood-brain barrier
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TARGETMOL CHEMICALS INC AH-7614 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist. purity: 99%
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TARGETMOL CHEMICALS INC AG 045572 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone. purity: 98%
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TARGETMOL CHEMICALS INC CDPPB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). purity: 99%
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Cayman Chemical BMS 753, Purity: ≥98%, CAS: 215307-86-1, 5 mg
A synthetic retinoid and RARα agonist (Ki = 2 nM); selective for RARα over RARγ at 1 μM; induces morphological differentiation of P19 embryonal carcinoma cells at 10 and 100 nM, as well as F9 embryonal carcinoma cells at 100 nM in combination with BMS649
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Cayman Chemical THUNDERPhospho-AKT pnT30 96Wel
Sandwich TR-FRET immunoassay for semi-quantitative detection of Phospho-AKT 1/2/3 (T308) in cell lysates
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Medchemexpress LLC Recombinant mouse SIRP alpha (CD172a) Fc-fusion protein | >90.0% | 50 UG
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Recombinant mouse SIRP alpha (CD172a) Fc-fusion protein produced in HEK293 cells, supplied as a purified Fc fusion for in vitro receptor-ligand interaction studies. The protein is provided as a 50 μg vial with reported purity greater than 90% and is suitable for biochemical and biophysical assays.
- Recombinant ectodomain fused to Fc for improved stability and avidity.
- Expressed in HEK293 cells to preserve mammalian post-translational modifications.
- Purity greater than 90% for reliable experimental performance.
- Compatible with ELISA, SPR/BLI, and other binding assays.
- Useful for studying CD47-SIRPα interactions and immune signaling pathways.
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Medchemexpress LLC Recombinant human cell adhesion molecule 2 (CADM2) | >95.0% | 10 UG
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Recombinant human cell adhesion molecule 2 (CADM2/IGSF4D) extracellular region (partial) produced in HEK293 cells and supplied as a His-tagged, lyophilized protein for research use. The protein is glycosylated, has an apparent molecular weight of ~40-57 kDa, and is provided with high purity and low endotoxin. Lyophilized from PBS (pH 7.4); store at -20°C and reconstitute to ≥100 μg/mL in ddH2O with carrier protein for long-term storage.
- Expression system: HEK293 cells.
- Tag: C-terminal 6xHis.
- Sequence: residues G30-D335 (partial).
- Molecular weight: ~40-57 kDa (glycosylated).
- Purity: >95.0% by reducing SDS-PAGE.
- Endotoxin: <1 EU/μg (LAL).
- Formulation: lyophilized from PBS, pH 7.4.
- Appearance: lyophilized powder.
- Storage: store at -20°C; aliquot to avoid repeated freeze-thaw.
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Selleck Chemical LLC Lodoxamide E4875-1G
Lodoxamide (U-42585E free acid) is a potent agonist of GPR35 with an EC50 of 1 nM It also inhibits eosinophil peroxidase release after IgA activation and reduces eosinophil cationic protein and eosinophil-derived neurotoxin suggesting direct effects on eosinophils It is a mast cell stabilizer used to treat asthma allergic conjunctivitis and superior limbic keratoconjunctivitis
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Cayman Chemical Ro 4929097, Purity: ≥98%, CAS: 847925-91-1, 1 mg
A potent, selective inhibitor of γ-secretase (IC50 = 4 nM) that blocks both Aβ40 and Notch processing (IC50s = 14 and 5 nM, respectively); orally active against cancer xenograft models, altering gene expression related to angiogenesis and cell differentiation
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