Bioactive Small Molecules
Cayman Chemical ANTIBODY NCB-0846 5mg
A TNIK inhibitor (IC50 = 21 nM); selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRα, TrkA, Cdk2/CycA2, and HGK by >80% at 100 nM; inhibits phosphorylation of TCF4 and autophosphorylation of TNIK in cell-based assays at 3 µM; inhibits the growth and colony formation of HCT116 cells in two-dimensional growth and soft-agar assays, respectively, as well as reduces tumor growth in an HCT116 mouse xenograft model; reduces tumor growth in PDX mouse models of colon cancer at 50 and 100 mg/kg
Medchemexpress LLC BMS-192364 50mg | 202822-21-7 | 355.70 g·mol⁻¹ | C15H9ClF3N3O2 | 50 MG
BMS-192364 is a small-molecule research compound described as an RGS (regulator of G-protein signaling) agonist. It modulates Gα-RGS interactions and alters calcium flux, and has been used in studies of urinary bladder contraction and G-protein-coupled signaling pathways. Supplied as a high-purity 50 mg vial for research applications.
- Targets Gα-RGS interaction as an RGS agonist.
- Modulates calcium signaling and reduces bladder contraction in models.
- Molecular formula C15H9ClF3N3O2.
- Molecular weight 355.70 g·mol⁻¹.
- Supplied purity 99.01% and packaged as 50 mg.
Cayman Chemical GBR 12909hydrochlorIde 5mg
A potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.
Cayman Chemical 11 Z 14 Z 17 Z-EIcosatrIen 5mg
Eicosatrienoic Acid (20:3ω-3) is a rare PUFA of the ω-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions which convert dietary C-18 fatty acids to C-20 eicosanoid precursors.{8460}
Cayman Chemical ANTIBODY ADU-S100 500ug
A cyclic dinucleotide STING agonist; induces IFN-β-dependent reporter activity in HEK293T cells expressing human STING, the human STING variants STING HAQ, STING REF, STING AQ, STING Q, or mouse STING at 10 µM; reduces tumor growth in wild-type, but not in Sting1-/-, mice in a B16/F10 murine melanoma model when intratumorally administered at 50 UG/tumor per day for three days; decreases primary and secondary tumor volume in a 4T1 murine breast cancer model of tumor rechallenge when intratumorally administered; unilateral intratumoral administration of ADU-S100 reduces tumor volumes in a bilateral CT26 murine colorectal cancer model; increases tumor infiltration of NK cells, CD4+ T cells, and CD8+ T cells , as well as increases immune cell-induced tumor necrosis, in a GL261 murine glioma model when intratumorally administered at 50 UG/tumor
Medchemexpress LLC Histamine dihydrochloride (Standard) | 56-92-8 | 99.96% | 100 MG
Histamine dihydrochloride (Standard) | 56-92-8 | 99.96% | 100 MG
Apexbio Technology LLC MK-0752(Synonyms: MK0752, MK 0752, MK-752, MK752, Gamma-secretase inhibitor MK-0752), 5mg, CAS: 471905-41-6.
MK-0752 (CAS 471905-41-6) is a small molecule inhibitor of -secretase an enzymatic complex responsible for proteolytic cleavage of the Notch receptor -secretase-mediated cleavage releases the Notch intracellular domain (NICD) thereby activating gene transcription essential for cellular differentiation proliferation and survival MK-0752 potently inhibits -secretase enzymatic activity with an IC50 of approximately 50 nM In vitro inhibition of -secretase by MK-0752 suppresses proliferation of breast cancer cells This compound has been investigated in clinical studies for advanced breast cancer and other solid tumors as well as pediatric refractory CNS malignancies underscoring its relevance for oncology research targeting Notch signaling
Medchemexpress LLC Bet-in-19 | 1643947-30-1 | 99.7% | 333.39 | C19H19N5O | 5MG
BET-IN-19 is a small-molecule BET bromodomain inhibitor used for preclinical research. It inhibits hIL-6 mRNA transcription and c-myc activity in human AML MV4-11 cells and disrupts tetra-acetylated histone H4 binding to BRD4 bromodomain 1. The compound is supplied as a solid and as DMSO solutions for biochemical and cellular studies.
- High purity (99.7%) suitable for research applications.
- Molecular formula C19H19N5O; molecular weight 333.39.
- CAS number 1643947-30-1 for unambiguous identification.
- Available as solid and concentrated DMSO solution formats.
- Recommended storage: powder -20°C; in solvent -80°C for long-term storage.
- For research use only; not for human or clinical use.
![Medchemexpress LLC N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide | 345627-80-7 | MFCD09833875 | 99.9% | 380.53 g/mol | C17H24N4O2S2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215367.png-250.jpg)
Medchemexpress LLC N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide | 345627-80-7 | MFCD09833875 | 99.9% | 380.53 g/mol | C17H24N4O2S2 | 50 MG
SNS-032 is a small-molecule research compound that selectively inhibits cyclin-dependent kinases CDK2, CDK7, and CDK9 (IC50s: 38 nM, 62 nM, 4 nM, respectively). It is used in preclinical studies to probe cell-cycle regulation, transcriptional control, apoptosis induction, and angiogenesis inhibition.
- Selective inhibition of CDK2, CDK7, and CDK9.
- Potent transcriptional inhibitor reducing RNA polymerase II phosphorylation.
- Demonstrated antitumor activity in preclinical cell models.
- Reversible activity suitable for washout and time-course studies.
- Available in small package sizes for laboratory research use.
Medchemexpress LLC Valopicitabine dihydrochloride | 640725-71-9 | MFCD34589916 | 98.0% | 429.30 g/mol | C15H26Cl2N4O6 | 1 ML
Valopicitabine dihydrochloride is the dihydrochloride salt of valopicitabine (NM-283), a 3-O-valine ester prodrug of the nucleoside analog 2′-C-methylcytidine with activity against hepatitis C virus (HCV). The material is supplied as a white to off-white solid and is available as pre-made research stock solutions (for example, 10 mM in DMSO, 1 mL). Product documentation provides a stock solution preparation table and guidance for preparing a range of concentrations for research use.
- White to off-white solid form.
- Purity 98.0%.
- Molecular weight 429.30 g/mol.
- CAS number 640725-71-9.
- Available as 10 mM solution in DMSO (1 mL) for convenience.
- Soluble in DMSO and water.
- Includes stock solution preparation table for multiple concentrations.
Medchemexpress LLC Spiroxamine | 118134-30-8 | 99.9% | 50 MG
Spiroxamine analytical standard (CAS 118134-30-8) is supplied as a high-purity liquid reference material for analytical and residue testing. It is intended for method development, calibration, and quantitative analyses using HPLC, GC, and MS.
- High purity of 99.9% (COA available).
- Suitable as an analytical reference for HPLC, GC, and MS.
- Molecular formula C18H35NO2; molecular weight 297.48 g/mol.
- Available in small pack sizes suitable for analytical workflows.
- SDS and certificate of analysis available for quality verification.
Apexbio Technology LLC LY2409881 25mg. 524-95-8. MFCD00014823
LY2409881 is a potent and selective inhibitor of IKK2 with IC50 value of 30 nM. IκB kinase β (IKK2) is an enzyme that serves as a subunit of IκB kinase, which is involved in the cytokine-activated immune responses. IKK2 activates nuclear factor kappa-B kinase (NF-κB). LY2409881 is a selective IKK2 inhibitor and exhibited >10-fold selectivity over other common kinases and IKK1. In the ovarian cancer cell line SKOV3, LY2409881 showed moderate cytotoxicity. While coadministration of LY2409881 and TNFɑ significantly induced cells death, which suggested LY2409881 inhibited NF-κB mediated antiapoptotic signals in a TNFɑ-dependent way. In the DLBCL cell line LY10, LY2409881 (10 μM) inhibited TNFɑ-dependent phosphorylation of IκB. In the DLBCL cell line SUDHL2, LY2409881 (10 μM) inhibited the nuclear signals of p50 and NF-κB. Also, LY2409881 induced apoptosis in a concentration-dependent way. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY KPT-276 10mg
An inhibitor of XPO1/CRM1; increases survival and reduces spleen weight and white blood cell count in an MV4-11 AML mouse xenograft model at 150 mg/kg; reduces tumor volume and increases survival in a BT 145 glioblastoma mouse xenograft model at 75 mg/kg
Medchemexpress LLC Deferiprone | 30652-11-0 | 100.0% | 100 MG
Deferiprone | 30652-11-0 | 100.0% | 100 MG
Cayman Chemical ZebrafIsh RetInoIc ACD Recep
zfRARαa Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments. [INDIGO Catalog No. Z02201-32, Z02201]